CHRONIC MYELOID LEUKEMIA
Kata Kunci:
Chronic Myeloid Leukemia, Philadelpia BCR-ABL, Bone Marrow Puncture, SitogeneticAbstrak
Objectives : Describe pathofhysiologyof chronic myeloid leukemia. Explain the coomon laboratory finding associated with chronic myeloid leukemia
Clinical Features : The clinical picture is generally non-specific, fluctuating fever, fatigue, night sweats, pain in the lower limbs
Intervention and Outcomes : Chronic Myeloid leukemia, bone marrow aspiration increased myeloid series and found young myeloblast cells
Conclusion: BCR-ABL fusion protein disrupts immature cell adhesion in bone marrow, activates mitosis and inhibits apoptosis, The diagnosis is made by examination of peripheral blood and bone marrow aspiration which is confirmed by conventional and molecular cytogenetic examinations such as FISH (Florescence in situ hybridization) for the identification of the Philadelphia chromosome.
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