A THE RELATIONSHIP OF GENETICS, COSMETIC USE AND LIPID PROFILE WITH THE SEVERITY OF ACNE VULGARIS IN 2024.

Abstract

Background: Acne vulgaris is still one of the main problems in teenagers with 85% of incidents from 14-19 years to early adulthood, namely over 20 years. The occurrence of acne vulgaris has a major influence on a person's psychological life and their quality of life which can often cause significant embarrassment in sufferers even though this disease is not life-threatening.

Objective: To determine the genetic relationship, use of cosmetics and lipid profile with the severity of acne vulgaris.

Research Method: This research uses the chi square test with analytical observations of primary data with sampling using random sampling techniques.

Results: From the research results mild degree (13.5%), moderate degree ((30.8%), severe degree (44.2%) with genetic frequency (yes = 67.3% no = 32.7%) , frequency of use of cosmetics (yes = 51.9%, no = 48.1%), and lipid profile (abnormal = 28.8%, normal = 71.2%) There is no relationship between genetics and mild acne vulgaris p – value 0.083 (> 0.05) (95% Confidence Interval 1.2143 and Chi square calculation 0.0624). However, genetics with moderate and severe acne vulgaris p value – 0.000 and 0.001 (<0.05) with (95% confidence). interval 0.2208 and 3.0357 and chi square calculations 10.643 and 13.655). There is no relationship between the use of cosmetics and mild and moderate acne vulgaris p value - 0.184 and 0.165 (>0.05) with (95% confidence interval 0, 3704 and 0.5556 chi square calculated 1.767 and 1.926) but the use of cosmetics was associated with severe acne vulgaris p value - 0.028 (<0.05) with (95% confidence interval 1.7593 chi square calculated 4.854). There is a relationship between the lipid profile and mild, moderate and severe acne vulgaris with p values ​​- 0.000, 0.025 and 0.000 (<0.05) with (95% confidence interval 2.500, 2.464, 0.081 and chi square 12.745, 5.039 and 20.605) . Multivariate results show that genetics is moderate (p value 0.002), the lipid profile is mild (p value 0.005), and the use of cosmetics is severe (p value 0.035).

Conclusion: From the results, there was no relationship between genetics and mild acne, however associated with moderate to severe acne. There was no relationship found between the use of cosmetics and mild to moderate acne, but it was associated with severe acne. And a relationship was found between the lipid profile and mild, moderate and severe acne at the Faculty of Agriculture, Indonesian Methodist University in 2024.

Keywords : Acne Vulgaris, Genetic, Cosmetic Use, Lipid Profile.