PENGARUH PEMBERIAN EKSTRAK DAUN MALAKA (PHYLLANTHUS EMBLICA LINN) PADA BERAT BADAN MENCIT BETINA (MUS MUSCULUS) DENGAN DIET TINGGI LEMAK JAUH

Abstract

abstract

Background:

Dietary fat is a major environmental factor that can influence the risk of obesity. Obesity is an increasingly common global problem. Children, adolescents, and adults in Indonesia generally have poor diets, characterized by excessive intake of foods and beverages high in fat, sugar, and salt or high fat, sugar and salt (HFSS) and insufficient consumption of fruits and vegetables. Malacca is a plant that is believed by the community as a traditional medicine that can cure various diseases, treat diabetes, as an analgesic, hepatoprotective, antipyretic, anti-inflammatory, anticancer, antihyperlipidemic, and antidiarrheal

Research objective:

To determine the effect of administering malacca leaf extract (Phyllanthus Emblica Linn) on the body weight of female mice (Mus Musculus) with a high saturated fat diet.

Research method:

This study is an experimental study with a pre-test - post-test with control group design. This study was conducted on female mice (Mus Musculus) as samples and divided into 4 groups, namely (P1, P2, P3) and a control group that was only given standard feed (P0). This study Data normality test was carried out using the Shapiro-Wilk test. To assess the comparison of body weight before and after administration of Malacca leaf extract, Repeated ANOVA was used if the data was normally distributed and the non-parametric Kruskal-Wallis test was used if the data was not normally distributed. Data is said to be significant if the p value <0.05. If the results of the statistical test using ANOVA or Kruskal Wallis show significant results, then further statistical tests are carried out using the Post Hoc Test to determine which treatment group shows the most significant results. Results of the study:

The data obtained were normally distributed and homogeneous, statistical analysis of pre-post mouse body weight with a paired T test showed a p value <0.05 at p0, p1, p2 and a p value> 0.05 at p3. The one-way ANOVA test showed a p value <0.05 and in the post hoc test, significant and insignificant values ​​were found on the average body weight of mice.

Conclusion:

There is an effect of giving Malacca leaf extract (Phyllanthus Emblica Linn) on the body weight of female mice (Mus Musculus) with a high saturated fat diet with a p value <0.05.

Keywords: Malacca leaf extract, high saturated fat diet, body weight of mice