EFEKTIVITAS AIR REBUSAN DAUN SIRIH MERAH (PIPER CROCATUM) TERHADAP KADAR GLUKOSA DARAH MENCIT JANTAN (MUS MUSCULUS) MODEL DIABETES MELLITUS

Abstract

Background: The incidence of Diabetes Mellitus in Indonesia has surged dramatically, rising from about 8.4
million people in 2000 to an estimated 21.3 million by 2030. Antidiabetic drugs and insulin treatments frequently
lead to side effects, highlighting the need for alternative therapies through traditional medicine. One promising
option is the red betel plant (Piper crocatum), which contains chemical compounds such as flavonoids, alkaloids,
and tannins that may help regulate blood glucose levels.
Objective: To observe the effectiveness of red betel leaf (Piper crocatum) decoction on blood glucose levels in
male mice (Mus musculus) as model for diabetes mellitus
Method: This study is experimental with a posttest-only controlled group design, involving 32 male mice with
diabetes mellitus, which are divided into 4 control groups. The data were assessed for normality and homogeneity,
and analyzed using one-way ANOVA.
Results: The average blood glucose levels were as follows: the control group without treatment (K1) had
190,17±84,05 mg/dL; the control group induced with alloxan (K2) had 351±103,6 mg/dL; the group induced with
alloxan 4.76 mg/20grBW and treated with 0.4 ml/20 gBW of red betel leaf extract (K3) had 297±96,05 mg/dL;
and the group induced with alloxan 4.76 mg/20grBW and treated with 0.5 ml/20 gBW of red betel leaf extract
(K4) had 158.50±46.06 mg/dL. The study results indicated a p-value of 0.003 (p<0.05), suggesting a significant
difference in average blood glucose levels among the groups.
Conclusion: Based on the study's findings, it can be concluded that boiled red betel leaf water (Piper crocatum)
at doses of 0.4 and 0.5 ml/20 gBW can lower blood glucose levels in male mice (Mus musculus) with a diabetes
mellitus model