Model Hiperglikemia dengan Pemberian HFD

Abstract

Background: Diabetes mellitus (DM) is a chronic metabolic disorder with dysfunction and/or insulin secretion, causing persistent hyperglycemia. Insulin resistance that is due to obesity is the one of the main pathology of metabolic syndrome and one of the risks that increases the possibility of type 2 diabetes is high intake of saturated fatty acids (HFD). Therefore, this study explores the effect of giving HFD for 30 days on blood glucose.

Subjects and Methods: This was a posttest only controlled group design study conducted in Universitas Methodist Indonesia with a total of 30 rats were divided into 6 groups. The rats will go through adaptation for 14 days. After adaptation, the blood glucose of the rats will be measured and then the mice will be given HFD for 30 days. During the HFD administration, the blood glucose of the rats will be measured every week for 4 times.

Results: Blood glucose did not increase after high-fatty diet administration for 30 days. The ANOVA test result showed that the p value > 0.05 which indicates that there is no difference between groups.

Conclusion: Providing High-fatty diet for 30 days has not been able to effectively increase blood glucose in rats, thus requires a longer period of time to administer high-fatty diet in rats to increase blood glucose.

Keywords: Diabetes mellitus, Obesity, High-Fatty Diet, Blood Glucose