A Analgesic Effect Of Ethanol Extract Of Chayote (Sechium Edule (Jacq.) Swartz) On Mice (Mus Musculus) Induced By Acetic Acid

Abstract

Analgesics are compounds that can relieve or suppress pain when used in therapeutic doses. An estimated 20% of the world's population experiences pain each year, and half of them are chronic. One of the medicinal plants that has an analgesic effect is chayote (Sechium Edule (Jacq.) Swartz).

Objective: This study aims to test the analgesic effect of chayote ethanol extract on mice induced by pain with acetic acid given orally.

Subjects and methods: This study, Mice were divided into 6 groups, namely the normal group, the negative control group, the positive control group, and the group that received ethanol extract of chayote at a dose of 40 mg/kgBW, 80 mg/kgBW and 120 mg/kgBW. Mice were acclimatized for 14 days and then given acetic acid to induce pain. After the mice experienced pain, they were given ethanol extract of chayote. The writhing tests were assessed every 5 minutes for 30 minutes.

Results: The decrease in writhing was better in the group given ethanol extract of chayote with a dose of 80 mg/kgBW.

Conclusion: Ethanol extract of chayote at a dose of 80 mg/kgBW can reduce writhing has good.

Background: Chayote, Analgesic, Acetic Acid, Writhing test