KEJADIAN MIOKARDITIS PASCA PEMBERIAN VAKSIN COVID-19 BERBASIS mRNA

Literature Review

Abstract

COVID-19 is still being a pandemic with high morbidity and mortality rate. In Indonesia, there were about 4 million cases with 150 thousand of them ending up in death. The approved COVID-19 vaccines have been successful in decreasing their morbidity and mortality rate, with mRNA-based vaccines such as BNT162b2 and mRNA-1273 having high efficacy. There are reports about the post-vaccination adverse events such as myocarditis, therefore a literature review was written about the problem. This article was made as a literature review, collecting previous research articles about myocarditis induced by the mRNA COVID-19 vaccine. Data collecting was done subjectively, without using any structured planning systematic and narratively presented. There are seven research articles investigating post-vaccination myocarditis, which 5 of them concluded about an increased risk of myocarditis event due to mRNA vaccine, one article stated that mRNA vaccine whether it is BNT162b2 or mRNA-1273, is safe to be used, and one article stated there is no correlation between myocarditis and mRNA vaccination due to a very small incident rate. mRNA COVID-19 vaccines are safe to be used due to their high efficacy in preventing severe clinical manifestations of SARS-CoV-2 infection. A post-vaccination adverse event like myocarditis is very rare and has a temporary and mild clinical manifestation in nature.