The Effect of Pare (Momordica Charantia L.) Fruit Extract Fraction on Reducing Blood Sugar, Insulin Resistance and Phosphatidyl Inositol 3 Kinase (PI3K) Signalling in Male Rats (Rattus novergicus) Streptozotocin-induced Hyperglycemia

Authors

  • Gustiany Nadya Damanik Universitas Methodist Indonesia
  • Hadyanto Lim Universitas Methodist Indonesia

DOI:

https://doi.org/10.46880/ijbhm.v1i1.734

Keywords:

Insulin Resistance, Phosphoinositide 3-Kinase

Abstract

Background: Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia as a result of impaired insulin secretion. The main cause of type 2 diabetes mellitus is a metabolic disorder characterized by insulin receptor resistance, reduced ability of pancreatic -cells to secrete insulin, and abnormal insulin secretion from cells of the pancreatic islets of Langerhans. In insulin resistance, the signaling defect in Phosphatidylinositol 3-kinase (PI3K) causes impaired glucose regulation in the body. The purpose of this study was to determine the effect of bitter melon extract (Momordica charantia L.) on lowering blood sugar, insulin resistance, and phosphatidylinositol 3kinase (PI3K) signaling.

Method: Literature review studies from related journals.

Results: Based on research conducted, it is known that bitter melon extract has an effect on blood sugar, insulin resistance, and PI3K signaling.

Conclusion: Bitter gourd extract has potential as an herbal antidiuretic drug.

 

Author Biographies

Gustiany Nadya Damanik, Universitas Methodist Indonesia

Student of Masters Program in Biomedical Sciences, Faculty of Medicine

Hadyanto Lim, Universitas Methodist Indonesia

Department of Pharmacology, Faculty of Medicine

References

Parawansah, Nuralifah & Noor Kholidha, A. Antidiabetic Test of Bitter gourd Extract (Momordica charantia L.) on Reduction of Blood Glucose Levels in Streptozotocin-Induced Mice. J. Ilm. 5, 410–415 (2017).

Adnyana, IDPA, Meles, DK, Wurlina, ., Zakaria, S. & Suwasanti, N. Anti-Diabetes Effects of Bitter gourd (Momordica charantia Linn.) on Blood Glucose Levels, Islets of Langerhans Composing Cells and Leydig Cells in Hyperglycemic White Mice. Acta Vet. Indonesia. 4, 43–50 (2017).

Anas, Y., Rositasati, R., Fitriani, MR & Suharjono. Development of an experimental animal model of type 2 diabetes mellitus due to insulin resistance. 16–23.

Maffei, A., Lembo, G. & Carnevale, D. PI3 kinases in diabetes mellitus and its related complications. int. J. Mol. science. 19, (2018).

Eszy, MS, Sastri, S. & Masri, M. Effect of High Palm Oil Diet on Blood Malondialdehyde Levels of Wistar Rats. J. Health. Andalas 3, 409–414 (2014).

Hernawati. POTENTIAL PARE FRUIT (Momordicha charantia L.) AS ANTIFERTILITY HERBAL.J. Univ. Educator. Indonesia. 18 (2011).

Rho, HW, Lee, JN, Kim, HR, Park, BH & Park, JW Protective mechanism of glucose against alloxan-induced -cell damage: Pivotal role of ATP. Exp. mole. Med. 32, 12–17 (2000).

Parawansah, P. et al.Effect of Bitter gourd Extract Fraction (Momordica Charantia L.) on Streptozotocin-induced Decrease in Rat Blood Glucose Levels. Maj. Pharmacy. 4, 84–92 (2020).

Suartha et al. Ethanol Extract and Hexane Fraction of Pare Fruit (Momordica charantia) as Blood Glucose Lowering Levels in Dia-betic Rats (ETHANOL EXTRACT AND HEXANE FRACTION OF MOMORDICA CHARANTIA DECREASE BLOOD GLUCOSE LEVEL OF DIABETIC RAT). J. Vet. 17, 30–36 (2016).

Ananta, MG, Suartha, IN & Dharmayudha, AAGO Effect of Partitioning Extra Ethyl Acetate of Bitter melon (Momordica Charantia) on the reduction of blood glucose levels in white rats (Rattus norvegicus) induced by Streptozotozine. Indonesia. Medicua Veterinus 5, 422–429 (2016).

Shih, CC, Lin, CH, Lin, WL & Wu, J. Bin. Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein [1] Parawansah, Nuralifah & Noor Kholidha, A. Antidiabetic Test of Bitter gourd Extract (Momordica charantia L.) on Reduction of Blood Glucose Levels in Streptozotocin-Induced Mice. J. Ilm. 5, 410–415 (2017).

Adnyana, IDPA, Meles, DK, Wurlina, ., Zakaria, S. & Suwasanti, N. Anti-Diabetes Effects of Bitter gourd (Momordica charantia Linn.) on Blood Glucose Levels, Islets of Langerhans Composing Cells and Leydig Cells in Hyperglycemic White Mice. Acta Vet. Indonesia. 4, 43–50 (2017).

Anas, Y., Rositasati, R., Fitriani, MR & Suharjono. Development of an experimental animal model of type 2 diabetes mellitus due to insulin resistance. 16–23.

Maffei, A., Lembo, G. & Carnevale, D. PI3 kinases in diabetes mellitus and its related complications. int. J. Mol. science. 19, (2018).

Eszy, MS, Sastri, S. & Masri, M. Effect of High Palm Oil Diet on Blood Malondialdehyde Levels of Wistar Rats. J. Health. Andalas 3, 409–414 (2014).

Hernawati. Potential Pare Fruit (Momordicha Charantia L.) As Antifertility Herbal.J. Univ. Educator. Indonesia. 18 (2011).

Rho, HW, Lee, JN, Kim, HR, Park, BH & Park, JW Protective mechanism of glucose against alloxan-induced -cell damage: Pivotal role of ATP. Exp. mole. Med. 32, 12–17 (2000).

Parawansah, P. et al.Effect of Bitter gourd Extract Fraction (Momordica Charantia L.) on Streptozotocin-induced Decrease in Rat Blood Glucose Levels. Maj. Pharmacy. 4, 84–92 (2020).

Suartha et al. Ethanol Extract and Hexane Fraction of Pare Fruit (Momordica charantia) as Blood Glucose Lowering Levels In Diabetic Rats (Ethanol Extract And Hexane Fraction Of Momordica Charantia Decrease Blood Glucose Level Of Diabet-ic Rat). J. Vet. 17, 30–36 (2016).

Ananta, MG, Suartha, IN & Dharmayudha, AAGO Effect of Partitioning Extra Ethyl Acetate of Bitter melon (Momordica Charantia) on the reduction of blood glucose levels in white rats (Rattus norvegicus) induced by Streptozotozine. Indonesia. Medicua Veterinus 5, 422–429 (2016).

Shih, CC, Lin, CH, Lin, WL & Wu, J. Bin. Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats.J. Ethnopharmacol. 123, 82–90 (2009).

Macfarlane, WM et al.The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic -cells. J. Biol. Chem. 272, 20936–20944 (1997).

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Published

2021-12-12