The Effect of Ethanol Extract and Fruit Fraction of Chayote (Sechium Edule (Jacq.) Swartz) on Oxidative Stress and Leptin Leptins in Wistar Brain White Rats (Rattus Novergicus Sp.) High-Fatty Diet Induced Obesity

Authors

  • Siska Veronika Universitas Methodist Indonesia
  • Jekson Martiar Siahaan Universitas Methodist Indonesia

DOI:

https://doi.org/10.46880/ijbhm.v1i1.731

Keywords:

Oxidative stress, MDA

Abstract

Background: The purpose of this study was to analyze the effect of ethanolic extract of chayote on oxidative stress of obese white rats of wistar strain (Rattus novergius Sp.) induced by a high fatty diet.

Method: This study uses a type of experimental laboratory research design post-test randomized controlled group. Researchers measured the effect of treatment (intervention) on the experimental group by comparing the experimental group with the control group. The sample was obtained by a simple random sampling method. Experimental sites and other research materials can be said to be homogeneous. This study will measure MDA levels as a biomarker of oxidative stress, IL-6 as a sign of inflammation, bodyweight as obesity, leptin levels as a biomarker of appetite and lipid profile levels. The research was conducted at the Biomedical Laboratory of FK UMI and started the acclimatization process, giving experimental animal surgery treatment at the animal house of FK UMI

Results: The results of the study concluded that the effect of chayote ethanol extract can affect oxidative stress which has potential as anti-obesity and hypolipidemia and antioxidants.

Conclusion: Ethanol extract and chayote fruit fraction have antiobesity

Author Biographies

Siska Veronika, Universitas Methodist Indonesia

Student of Masters Program in Biomedical Sciences, Faculty of Medicine

Jekson Martiar Siahaan, Universitas Methodist Indonesia

Department of Physiology, Faculty of Medicine

Department of Molecular Biology, Masters Program of Biomedical Sciences, Faculty of Medicine

References

TE Warkentin, “HIT as a preventable disease?,” Blood, vol. 106, no. 8, p. 2600, 2005, doi:10.1182/blood-2005-07-2977.

JG Vaamonde and MA lvarez-Món, “Obesity and overweight,” Med., 2020, doi: 10.1016/j.med.2020.07.010,

MF Coss-Rovirosa et al., “Are overweight and obesity risk fac-tors for invasive mechanical ven-tilation in severe coronavirus dis-ease 2019 pneumonia?,” Arch. Endocrinol. Metab., 2021, doi: 10.20945/2359-3997000000350.

FQ Nuttall, “Body mass index: Obesity, BMI, and health: A criti-cal review,” Nutrient. Today, vol. 50, no. 3, pp. 117–128, 2015, doi:10.1097/NT.000000000000009.

EYC Ting, AC Yang, and SJ Tsai, “Role of interleukin-6 in depres-sive disorder,” International Jour-nal of Molecular Sciences. 2020, doi:10.3390/ijms21062194.

JM Siahaan, S. Illyas, D. Lindarto, and M. Nainggolan, “Effect of Ethanol Extract of Chayote (Sech-ium Edule Jacq. Swartz) on Insu-lin Resistance in Rat with Diabe-tes Mellitus Type 2 Induced by Streptozotocin-Nicotinamide-High Fat Diet, ” pp. 340–340, 2019, doi:10.26911/the6thicph.05.05.

S. Salazar-Aguilar et al., “Sechium edule (Jacq.) swartz, a new culti-var with antiproliferative poten-tial in a human cervical cancer HeLa cell line,” Nutrients, vol. 9, no. 8, pp. 1–15, 2017, doi:10.3390/nu9080798.

J. Rosado-Pérez, I. Aguiñiga-Sánchez, E. Santiago-Osorio, and V. M. Mendoza-Núñez, “Effect of Sechium edule var. nigrum spi-nosum (Chayote) on Oxidative Stress and Pro-Inflammatory Markers in Older Adults with Metabolic Syndrome: An Explor-atory Study,” Antioxidants, vol. 8, no. 5, p. 146, 2019, doi:10.3390/antiox8050146.

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Published

2021-12-12